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Postal 2, a 2003 PC game known for open-ended design and "offensive" humour that ran the gamut from wannabe-South-Park to downright ugly, recently did something pretty clever.
There are only three controls in EpiPen Tycoon. You can increase the price of an EpiPen by $5, reduce it by $5 or, in the rare occasions that the public gets too mad at you, deploy a few outrage-deflating special bonuses. The goal is simple. You, Heather Bresch, are the CEO of Mylan. You want to make as much money as possible by selling EpiPens. If your customers die, they die.