Controlling a cockroach or an entire ant colony is pretty unusual, even for a video game. So we can say games featuring these ideas resulted in rather unique and underrated titles -- and that's absolutely not a problem.
We collected some of the most interesting ones below.
SimAnt: The Electronic Ant Colony
Source: Killerratte's LP
Battle Of Giants: Mutant Insects
The Zerg In StarCraft I and II
Source: Vysethedetermined2's LP
Source: KakeyoSilverton's LP
Source: KawaKasper's LP
A Bug's Life
Source: OzcrashSoNiC's LP