Headstrong, developer of House of the Dead: Overkill, thinks they can. In this video, the creative staff discuss the game's grindhouse style and how this won't necessarily be a rail shooter.
Of course, this isn't the first M-rated game for the Wii. Seventeen titles have gotten it for "Blood and Gore" even. But it's definitely a departure from the stereotype, especially for a Wii exclusive. Given House of the Dead's long legacy as an arcade shooter, it's probably the only machine for which this type of game could be developed. It'll be curious to see how this does against Dead Rising: Chop Til You Drop.
House of the Dead: Overkill: The Experience Doc [Gametrailers]