How can we tell? It's not the visual clarity or high-res 3D models on the Transformers: Revenge of the Fallen box art. It's the sparks! Everyone knows that particle effects like that require serious hardware.
Unfortunately, my theory is blown when one realises that the same box art is being used for the PlayStation 2 version. Arguments about it being employed on the Wii and PSP versions will have to be made amongst yourselves.
Say what you want about Michael Bay's take on the Transformers, but at least the video game adaptation of the movie sequel's box art hides the goofy mouths on Optimus Prime and... is that the Fallen back there? Afraid I can't say the same for the Nintendo DS versions, which feature a snagletoothed Megatron and a deer-in-the-headlights look from the Autobot leader.