While terrifying glimpses of BioShock 2's Big Sister and creepy Little Sisters are enough to satiate Western audiences, the cover of a recent issue of Taiwan's Famitsu Weekly takes a decidedly more Eastern approach.
GameSetWatch highlighted this anime take on two of gaming's creepier characters, which takes a great deal of the creepy away, filling the void with a cuteness that while completely adorable, is completely out of character for the BioShock universe. Even so, I'd probably still play whatever game the Taiwanese think might think they'd be getting based on that cover art. Maybe if I keep this picture around when BioShock 2 comes out I won't be quite as unnerved.
Big Sister's Evolution, Anime-Style Design [GameSetWatch]