Naughty Dog's Amy Hennig told Playstation.Blog that Nathan Drake is "going to have a lot of adventures" past Uncharted 2. What is said here—very successful IP will continue—isn't news. Yet again, what's unsaid is.
[Uncharted 2]doesn't conclude the story at all. The expectation with Uncharted 2 is that it can be an ongoing franchise as long as people want more of it. All these stories are self-contained. You don't have to play the last one to play this one. Obviously, you're going to get a little bit more out of it if you have. But [Nathan Drake] 's going to have a lot of adventures, thank God.
I read between the lines of Hennig's quote and find she's not talking about the form factor in which Uncharted will be sequelisid. So I consider it another big tease for episodic DLC for the game. The only word on DLC before was lead designer Neil Druckmann's coy "We are working on that," in a video interview back in May.
Uncharted 2 Interview with Naughty Dog Plus Behind-the-Scenes on X-Play Tonight [PlayStation.blog via Play.tm]