When last we heard about Natal, and the possibility of air guitaring Guitar Hero, a Neversoft producer said they were "interested". If they're not, RedOctane is. Their president just upgraded the Natal/Guitar Hero connection to "likely."
In an interview with Digital Spy, Kai Huang, president and cofounder of RedOctane, said the studio has "definitely been evaluating Microsoft's Natal technology, along with a lot of other different technologies".
Natal is very interesting because there's so many different things you can do with it, whether it's the motion detecting, maybe sensing how you're playing, or the ability to use it for interactivity purposes and taking advantage of it for party purposes. I think the technology is very exciting. We're evaluating it, and I think it's likely that sometime in the future we'll have those technologies integrated into our games.
Rock Band also is considering Natal, saying they'd look at the technology for inclusion in Rock Band 3.
Guitar Hero May Use Natal Technology [Digital Spy]