Take a look at how classic Spider-Man villains Hammerhead, Kraven the Hunter and the Goblin fare in the transition to the continuity-crossing Spider-Man: Shattered Dimensions.
The shattering of the Tablet of Order and Chaos did a number on the Green Goblin, but left Hammerhead and Kraven mostly intact, which makes sense, I suppose. Kraven hunts in the original Marvel universe, after all, and Hammerhead looks so much like a Dick Tracy villain that a trip to the noir 1940s is like a homecoming for him.
Poor Normal Osborn, on the other hand, has been transformed into some sort of rampaging beast. It's certainly not your traditional goblin, but I suppose this isn't your traditional Spider-Man game either.
At least they aren't doing anything silly, like having Kraven shoot himself in the head.