Sega's Yakuza series began in 2005 when the first game was released in Japan on the PlayStation 2. A sequel followed the following year, and to date there have been five games.
That includes one spin-off. Another spin-off is slated for the PSP later this year.
An ad depicting the a destroyed Kamurocho, the in-game version of Shinjuku's Kabukicho, appears in the new issue of Japanese game mag Famitsu. The text reads, "The End".
Sega has previously revealed a new Yakuza game. The title does not have a release window, but the game's developers have said the theme is "destruction". Sure looks like it.
Thanks Carlos for the tip!