Somehow the theme song for 2005's Civilization IV is being nominated for a 2011 Grammy. The makers of the game have said that Christopher Tin's Baba Yetu would become the first gaming song to win one. But it's got competition.
There are four other songs in the Grammys' Best Instrumental Arrangement Accompanying Vocalist(s), one of 109 categories for the awards.
So all Civ's got to worry about is Bobby McFerrin, a celebrity cover of John Lennon's Imagine and a couple of others. Good luck!