Having recently become a parent, I can say that the loss of my child is one of the most terrible things I can imagine. I don't know if I'd want to play that tapping into the emotions surrounding such an event.
At E3 last week, our own Chris Person took a look at the game made by student from the Danish Academy of Digital Interactive Entertainment and got one of those developers to talk about the design ideas behind A Mother's Inferno. As harrowing as the journey seems, I do like the idea using a game as a experiential metaphor for moving past a terrible life experience. You can check out more info on A Mother's Inferno here.