Face it: we're never going to get a game where Thor, Optimus Prime Boba Fett and Commander Shepard team up to save all of reality. But deviantart user lonefirewarrior has given us the next best thing.
Using Garry's Mod, Photoshop and a whole lot of patience, deviantart user lonefirewarrior has created Vindication, a multi-franchise mash-up series of artworks where the heroes of a whole lot of video games team up, get depressed and smoke cigarettes. Oh, they apparently gamble and fall in love, too. Here's how he describes it:
A music inspired Garry's Mod series involving a monumental war set in a sci fi universe in which the depicted characters and their respective universes have always existed as one.
Stuff like this is why deviantart exists, right? Check out the whole gallery here.