This is "Trigger Finger" from Lil Wayne's newest album I Am Not a Human Being II, released Wednesday. But Mass Effect fans should recognise that opening sample, before it lights up a bowl and rolls into the filth-flarn-filth lyrics (so, yes, NSFW warning if you're listening around others over speakers.)
"It is almost unmistakably a sample from one of the main themes from Mass Effect," says reader Aethops, and I concur. I think this is interstitial music heard very early in the original game, aboard The Citadel.
Sampling video game soundtracks. Good thing? Not a good thing? Did Weezy do it justice? Can we get some Jespyr Kyd next time?