The Sinister is a gaming mouse/controller/thing currently up on Kickstarter that looks, well, nothing like a gaming mouse. The idea is similar to that of R.A.T.7, which got an A for effort but a C- for comfort.
The Sinister looks to get around that by not being slightly customisable, but entirely customisable.
You can pivot, rotate and slide the major components into any configuration you deem comfortable, and it also has some fancy inputs that let it mimic either a PC mouse, keyboard controls or Xbox pad. It also has haptic feedback.