Browsing German artist HeavyMetalHanzo's gallery and realising how much potential some video games and video game worlds have as Western cartoons or comics makes me sad. Most of these will probably never get such a treatment, and these amazing pieces remain the closest things.
Here's some of Hanzo's recent work. Check out his profile for a lot more:
Child of Light:
Zero Suit Samus:
Heavy Metal Lightning from Final Fantasy XIII (this one's so awesome):
Heavy Metal Hanzo's Art [DeviantART]