Bioware just unveiled a new Mass Effect during EA's press conference at E3, and it looks gorgeous. The game seems to be in an early development stage — some of the footage/shots was labelled as conceptual — but Bioware spoke of how they're listening to fans and taking the franchise in new directions. We caught shots of new planets and old familiar races, such as Krogans.
Watch for yourself, in the footage above.
The protagonist, for what it's worth, is not Commander Shepard (hopefully this isn't surprising). It did look like the protagonist might be a human though.