Deus Ex is arguably the greatest PC game ever made. So how about a Let's Play of it, with Phil Spector, Sheldon Pacotti and Chris Norden -- they only made the damn game.
I don't know about you, but I'd kill for more videos like this. Imagine a Let's Play of Super Mario Bros. with Shigeru Miyamoto, or a Let's Play of Dark Souls with Miyazaki?
Seriously, more of this kind of thing please.