Announced earlier today, Noita is a rougelite that promises to blend magical action with a world where "every pixel is physically simulated".
Noita's only just been announced, so it's hard to say how much variety there is with the in-game interactions. I can imagine plenty of different spell-based interactions with the environment though: setting sheets of ice to make enemies trip or slide, obscuring enemy attacks with clouds of smoke from random fire, or using projectiles to drop spears on the enemies below.
Either way, it should be interesting. The developers' previous games include The Swapper and Crayon Physics Deluxe, both of which were very cool. There's no release date yet, but you can keep track of the game through the official website, or their dev blog.