You probably best know Galactus as either the Devourer of Worlds or perhaps even Squirrel Girl's BFF. Though, for the past few years, the greatest threat to the Marvel Cosmos has actually been one of its greatest protectors. But Marvel's upcoming Infinity event has just forced the interstellar entity down another path.
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There are certain comic book characters whose characterisations are so canonically static that it becomes difficult to imagine them ever changing in a significant way. Take Galactus for example. Since he was first introduced in Fantastic Four #48, he's has done little else than threaten to devour planets.
The Ultimates came together to safeguard the world from the biggest threats in the Marvel cosmos -- and then Civil War II happened, some people got hit in the face with a chair and, eventually, the Ultimates disbanded. But the threats they faced never went away, and now they're back in action... with a few twists.