I'm really looking forward to Return of the Obra Dinn, the next game from Papers, Please creator Lucas Pope. The version at PAX West is much improved from the early demo you may have played, with a much more extensive "ship's log" interface that lets you keep track of all the murder mysteries you have to solve by reliving people's moments of death as you explore a ship in classic Macintosh-style monochrome. It shouldn't be long now before it's out.
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Echoing Mark's thoughts, I've a good feeling that quite a few of the year's best titles will be the ones that we simply haven't heard of. Take the Nintendo Switch: nobody knows what's landing on that this year. And then every year has little indies that pop up out of nowhere, like Stardew Valley last year, or Her Story the year before that.
With that in mind, here's the games that we do know about - and the ones I'm most excited for.