With the game finally out for all and sundry, people are binging Fallout 4 left, right and centre. Bethesda's Pete Hines even tweeted out a permission slip this morning for people taking sickies off work (props to anyone ballsy enough to use it).
Naturally, the PC is the lead platform and it's where people will experience the fewest performance issues. That's provided, however, you're using a NVIDIA card.
A set of benchmarks has appeared on the German site PC Games Hardware, and if you're an AMD fan then the figures aren't good. In fact, they're actually pretty awful.
NVIDIA doesn't just come out ahead in the figures: they're so far in front, that the Sapphire R9 Fury and the HIS R9 390X are actually losing to an GTX 970 and a GTX 780 Ti in 1080p. Ouch.
The story doesn't get better at higher resolutions either: the Fury and 390X continue to play second fiddle, although not by much, to the 780 Ti and the GTX 970 at 1440p, although the Fury X regains a measure of respectability at 4K by achieving a fraction over 30 FPS on average. (The GTX 980 was on par, the 980 Ti was far superior and the 780 Ti and GTX 970 were several frames behind at 4K.)
You can check out the rest of the graphs and the remainder of the specs used at PCGHW. Most of the text is in German,but all the specs and the key figures you need are in English so you shouldn't have any trouble parsing it all. NVIDIA has also got another major driver release coming out soon, and if their track record this year is anything to go by that gap could widen.