The success of games such as Plague Inc. show that there's something rather enjoyable about making your own diseases, mutating strains and fiddling with genes. If you've been looking for something deeper -- a similar sort of game with RTS mechanics and based on actual science -- you might want to bookmark Cryogenic Entertainment's CURE.
The website describes the game as an RTS, but there's a bit more to it. Like Impossible Creatures and Spore, you construct your units piecemeal. In this case, you tweak their DNA to give them different behaviours and abilities.
The cool part is that the game is based on "microbiology and real life genetic engineering", so it'll be partially educational too. And once you've got your bugs the way you want, you'll be able to pit them up against "millions of other players"... though not right now, CURE is still in development.
What immediately stands out is how gosh darn pretty the thing is. Take this screen -- it's like the Fallout 4 face editor... except for microbes.
As to how it plays, here's a gameplay clip with commentary.
Sadly, the game isn't available just yet. However, the developer is accepting alpha sign-ups if you'd like to check it out.
C.U.R.E. [Official website]