When Bowser dies at various points in Mario & Luigi: Bowser’s Inside Story, the brothers have to revive him by shooting adrenaline into his heart. Doing so leads him to get back up and become giant Bowser for a special mode that requires players to hold the DS sideways like…
Anyone who hasn’t played the original on DS shouldn’t bother at this point. The remake is better-balanced and better-looking, arriving with a fair bit of extra side content as well.